The Effect of Biochemical Parameters In Early Onset And Late-Onset Preeclampsia Compared To Normal Pregnancy
DOI:
https://doi.org/10.70135/seejph.vi.2618Keywords:
Preeclampsia, early and late onset, biochemical parameters, urine protein, urine creatinineAbstract
Preeclampsia (PE) is a life-threatening pregnancy condition exhibited by high blood pressure and the protein in the urine which causes endothelial injury and altered coagulation balance with occasional subtypes dependent on the time of onset. The target of this research was to portray the biochemical indices that is seen in normal pregnancies, early-onset preeclampsia (EOPE), and late-onset preeclampsia (LOPE). The study is composed of parameters like urinary protein, Urine creatinine, and urinary protein/ creatinine ratio, serum aspartate aminotransferase (AST), and alanine aminotransferase (ALT). The group's specific divergence were observed between the EOPE and LOPE groups compared to normal pregnancies. Such differences might suggest some unique biochemical profile of EOPE and LOPE. Strikingly, the level of urine proteins were 9.3 and 0.7 times higher than the normal level in patients in the EOPE and LOPE stages with both preeclampsia subtypes being affected by common kidney dysfunction. Also, EOPE showed increased urine creatinine and levels of AST in comparison with LOPE and healthy pregnancy, which signified the hepatic and renal damage as being accentuated in the cases of early onset. Normality proves its validity only for some of the parameters indicated by the test, and the same goes for the test of equal variance. There are still some tasks to be completed to evaluate and understand completely one of the most problematic pregnancy complications – pre-eclampsia. Overall, the present study has shown the possible biochemical profiles attributable to the diverse subtypes of preeclampsia and thus provides definite information on the pathogenesis of the condition. The results will fill in the gap in the knowledge related to preeclampsia and could be used as an indication, helping to detect and treat the disease more successfully in the future.
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