Some Novel Series of 3-Alkylidene 3-Phenylthio-3-Chloro Azetidine -2-One Were Synthesized by The Staudinger Ketene-Imine Cycloaddition and Evaluation of Their Biological Activity

Authors

  • Thakor Patel Shiva performance materials Pvt ltd, Shiva Building, Sarabhai compound, Sarabhai Road, vadiwadi, Vadodara, Gujarat, India.
  • Bhavik Hemant Kumar Panchal Department of Chemical science, Parul institute of applied sciences, Parul university, Vadodara, Gujarat, India.
  • Shanta Raj Lakshmi Department of Chemical science, Parul institute of applied sciences, Parul university, Vadodara, Gujarat, India.

DOI:

https://doi.org/10.70135/seejph.vi.1940

Keywords:

Anti-inflammatory, Analgesic, Ulcerogenic activities and toxicity studies.

Abstract

Various series of 3-alkylidene 3-Phenylthio-3-Chloro azetidine -2-one(5) synthesized by reaction of 1- (4'-Methoxyphenyl)-3-chloro-3-phenylthio-4,4-diethoxycarbonylazetidin-2-one (4) with thionyl chloride taking MDC as solvent while synthesis of Compound 4 carried out the reaction between phenyl thio acetic acid and N-(4-Methoxyphenyl)-1,1-diethoxycarbonylimine (2) while compound second synthesized by staring material diethyl keto malonate and p-anisidine. these newly synthesized compound were evaluate using different analytical tools These compounds were also evaluated for their anti- inflammatory and analgesic activities.

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Published

2024-10-31

How to Cite

Patel, T., Panchal, B. H. K., & Lakshmi, S. R. (2024). Some Novel Series of 3-Alkylidene 3-Phenylthio-3-Chloro Azetidine -2-One Were Synthesized by The Staudinger Ketene-Imine Cycloaddition and Evaluation of Their Biological Activity . South Eastern European Journal of Public Health, 1014–1020. https://doi.org/10.70135/seejph.vi.1940

Issue

Volume XXV S1 2024

Section

Articles

License

Copyright (c) 2024 Thakor Patel, Bhavik Hemant Kumar Panchal, Shanta Raj Lakshmi

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This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.