Investigation Role of IL-10 And IL-13 with Some Viral Species in Pathogenesis of Heart Diseases

Abstract

Background; cardiovascular disease (CVD) is the most common cause of mortality and impairment. Atherosclerosis is the primary underpinning pathophysiology of CVD, but several variables could trigger it. The occurrence of it is linked to multiple risk factors related to metabolism, such as overweight and dyslipidemia.

Objective; Detective predictive  roles  of IL-10 and IL-13 and positivity of viral infections  in heart diseases.

60  blood samples were harvested (gel tube)  from heart diseases patients who sleeping in hospital after diagnosis them by specialist  physician.30 blood samples were taken from healthy individuals that labeled them as a control  group. Interleukins (IL-10 and IL-13)  and  viral species (Parvovirus B19, SARS-CoV-2, HCV and HBV) were  calculated by (ELISA).  

Present outcomes mentioned the most patients were males (71.7%) with age groups 51-60 (26.7%) and 61-70 (33.3%), ex-smokers (65.0%), and lean BMI (63.3%). Our investigation showed Parvovirus B19 scored highest positivity (15.0%), followed by HBV (6.7%), SARS-CoV-2 (5.0%), and then HCV (3.3%) in heart diseases patients with significant difference (p<0.05). Based on interleukins levels, present outcomes showed significant raised levels (p<0.05) of IL-10 and IL-13 in patients than control. ROC curve results showed the IL-13 scored highest sensitivity (80%) and specificity (84%) at cut off (>2.50) compared to IL-10 that showed highest sensitivity (81%) and low specificity (57%) at cut off (>9.50).

Conclusions; gender, age and smoking are risk factors for heart diseases. Due to decreased immune state in patients, several viruses were discovered in those patients. IL-10 and IL-13 were raised in patients due to presence inflammation. IL-10 has paradoxical role (pro and anti-inflammatory) in pathogenesis heart diseases . IL-13 is more preferred in diagnosis heart diseases than IL-10 due to has (IL-13) highest sensitivity and specificity. Finally, there is no strong correlation between  IL-10 and IL-13 in pathophysiology of heart diseases.