Formulation Development And Evaluation Of Transdermal Patch By Using Natural Polymer And Niaouli Oil As A Permeation Enhancer

Abstract

Since oral bioavailability of Isradipine is poor due to high first pass metabolism different matrix. Transdermal applications, relative to other routes, are non-invasive, requiring the simple adhesion of a “patch” resulting in better patient compliance, improved bioavailability of a drug, and easy treatment termination. Hence, this investigation, aimed at delivering Isradipine across intact skin as a membrane-moderated transdermal therapeutic system of Eudragit R100. Optimized batch was evaluated for permeation enhancement through rat skin using natural permeation enhancer Niaouli oil and it can concluded that permeation enhancement through Skin. Niaouli oil comparable to commercially available permeation enhancer DMSO.