Formulation And Characterization Of Root Extract Of Punica Granatum L. Containing Ointment Against Bacterial Pathogens

Abstract

The potential antimicrobial activity and physicochemical characteristics of a ointment containing roots of Punica granatum L. were examined. The antimicrobial activity was carried out by performing agar well diffusion method. Antimicrobial efficacy of aqueous and ethylacetate solvent extract of roots of Punica granatum L was evaluated against E.coli and Staphylococcus aureus. The extracts which showed better results were chosen for formulation of ointment. We created an ointment by mixing 10% w/w aqueous extract of Punica granatum into an aqueous cream. The homogeneity, spreadability, extrudability, pH, viscosity, the ointment formulation were all evaluated. These results imply that a herbal ointment derived from Punica granatum is a potent topical formulation that combines contemporary pharmaceutical technology with traditional herbal medicine to treat skin infections.