Innovative Topical Gel Formulation: Fusidic Acid and Diclofenac Microparticles for Enhanced Wound Healing

Abstract

Wound healing is an intricate biological process involving a coordinated interplay of cellular, molecular, and biochemical events to restore tissue integrity. Topical Drug delivery systems have garnered considerable attention for their capability for localized and sustained release, minimizing systemic side effects. This study presents a novel gel formulation incorporating fusidic acid and diclofenac-loaded micro particles to enhance wound healing. Fusidic acid serves as a potent antibacterial agent, while diclofenac offers anti-inflammatory properties, together addressing two critical aspects of wound care: infection control and inflammation management. The gel matrix ensures prolonged drug retention and controlled release, promoting re-epithelialization and tissue regeneration. In vivo wound closure studies conducted on a murine excisional wound model revealed that wounds treated with the micro sponges gel showed significant wound contraction, with the percentage closure increasing from 10.05% on day 4 to 90.51% by day 21, compared to 9.68% in the untreated control group and 97% in groups treated with individual standard drug formulations by day 21. These findings underscore the synergistic potential of fusidic acid and diclofenac microsponge in accelerating wound healing and highlight the formulation as a promising candidate for clinical application in wound management. Further studies are warranted to evaluate its efficacy in chronic and infected wounds.