To study the correlation of serum ST-2 levels with absolute eosinophil count in COPD patients

Abstract

Background: COPD is chronic lung disease associated with frequent disease exacerbations and poor quality of life. COPD patient with eosinophilic inflammation phenotypes are under increased risk for exacerbation. Thus the master switch of inflammation i.e.IL-33/ST-2 pathway can be blocked by using anti-ST2 monoclonal antibodies and further complication of COPD can be minimized. Thus we aimed to study the correlation of absolute eosinophil count with ST2 in COPD patients. In order to investigate the concentration of serum ST-2 (suppression of tumerogenicity 2) receptor and its correlation with absolute eosinophil count we recruited 150 COPD patients and 150 healthy controls in our hospital and divided into two subgroups; smokers and non-smokers. When we compared serum ST-2 of COPD patients with healthy controls, a significantly higher level of serum ST-2 was found in COPD patient as compared to healthy control. The positive correlation of AEC and ST2 in COPD patients as well as healthy control subjects were recorded, which confirms the role of ST2 receptor mediated eosinophilic inflammation in COPD patients via IL-33 activation.