Pharmacological Effects Study and Safety of Andrographis Paniculata Fever Medicine Recipe

Abstract

Fever medicine recipe G531/64 is an herbal recipe containing Andrographis paniculata formulated for treating COVID-19. The capacity of the recipe was evaluated by chemical and pharmaceutical analysis. Total phenolic content of the recipe was 137.70 mg GAE/g. The extract of the recipe at 1 mg/mL showed slightly lower ORAC and FRAP antioxidant activity than L-ascorbic acid at the same concentration. The concentration that reduces 50% of cell number (IC50) was 60.29 µg/mL. G531/64 at 100 µg/mL exhibited 77.65% anti-inflammation which was higher than those of Lopinavir (65.29%) and Ritonavir (60.35%) with the same concentration. The results from this study indicated the feasibility of using G531/64 as an alternative drug for treating COVID-19.