Uncommon Clinical and Biochemical Presentation of Scrub Typhus - An Observation Study

Abstract

Background: Scrub typhus, a neglected tropical disease, poses a significant threat to public health. Early diagnosis and treatment are crucial to preventing mortality.
Methods: A retrospective study of 240 patients diagnosed with scrub typhus was conducted to analyze the prognostic value of immature platelet fraction (IPF) and peri-gallbladder edema.
Results: Low IPF (<10%) was associated with higher mortality (p<0.01), while elevated IPF (>20%) was linked to better outcomes (p<0.05). Peri-gallbladder edema was identified as a significant diagnostic marker, with a higher incidence in mortality cases (63.3%, p<0.001).
Conclusion: This study highlights the potential of IPF and peri-gallbladder edema as novel prognostic markers in scrub typhus. Low IPF and presence of peri-gallbladder edema may indicate a higher risk of mortality, warranting prompt and aggressive treatment. These findings may aid in the early identification and management of severe cases, ultimately improving patient outcomes.