Immunomodulatory Effects Of Lactobacillus Plantarum NC8 In Poultry: Enhancing Immune Response Against Salmonellosis

Abstract

Salmonella Gallinarum is a major pathogen in poultry, causing fowl typhoid and significant economic losses. This study investigates the immunomodulatory effects of Lactobacillus plantarum NC8 in enhancing resistance against S. Gallinarum infection. A total of 45 chicks were divided into experimental groups and administered different doses of L. plantarum NC8. Birds that received a double-dose regimen (Day 1 and Day 10) revealed reduced tissue damage in the vaccinated groups compared to controls in histopathological analysis. The expression of key cytokines (IL-4, IL-10, and IL-17) was significantly upregulated, suggesting a balanced immune response that enhances both protection and immune regulation. These findings highlight the potential of Lactobacillus plantarum NC8 as a probiotic intervention to improve poultry immunity and reduce Salmonella infections, offering a natural and sustainable alternative to antibiotics in disease control.