Comparative Clinical Efficacy of Pathyadi Ointment and Standard Market Preparation Ointment in Vicharchika (Eczema)

Abstract

Vicharchika, classed as Kshudrakushtha in Ayurveda, has clinical similarities with eczema in modern dermatology. This study compares the efficacy of Pathyadi Ointment to a Standard Market Preparation Ointment on subjective and objective measures in children with Vicharchika. A total of 60 patients were randomly allocated to one of two groups: Pathyadi Ointment or Standard Market Preparation. Over a 12-week period, the study evaluated improvements in symptoms such as Kandu (itching), Daha (burning feeling), and Rukshata (dryness), as well as objective measurements such as the SCORAD index and absolute eosinophil count (AEC).
The results showed considerable improvements in both groups, with Pathyadi Ointment outperforming the other in terms of symptom reduction and overall patient satisfaction. Statistical analysis utilizing ANOVA and Mann-Whitney tests showed Pathyadi Ointment's efficacy, with p-values < 0.05 for all important parameters. These findings highlight Pathyadi Ointment's potential as an effective, safe, and cheap treatment for Vicharchika (eczema) in pediatric populations. More study with larger sample sizes and longer follow-ups is needed to corroborate these findings.
While the study demonstrated significant improvements in subjective symptoms such as itching, burning, and dryness, as well as objective parameters like the SCORAD index, the absolute eosinophil count (AEC) changes were not statistically significant. This outcome is likely due to the localized nature of the Pathyadi Ointment application, which primarily addresses topical symptoms rather than systemic allergic responses. These findings emphasize the role of Pathyadi Ointment as an effective topical treatment for Vicharchika while highlighting its limited impact on systemic biomarkers like AEC.