Study of Central line related blood stream infection in intensive care units and its role in Biofilm formation: A Microbial Perspective

Abstract

Introduction: Central line-related bloodstream infections (CLRBSIs) are a significant cause of morbidity and mortality in intensive care units (ICUs). The development of biofilms on central venous catheters (CVCs) serves as a critical factor in the pathogenesis of these infections.Aims and Objectives:1.To investigates the prevalence, microbial profile of central line-related bloodstream infections (CLRBSIs) in intensive care units (ICUs) and to explore the relationship between biofilm formation, antimicrobial resistance. 2: To determine the rate of central line related blood stream infection (CLRBSI).Materials and Methods: This prospective observational study was conducted in the ICU of a tertiary care hospital. Patients with suspected CLRBSIs were enrolled, and central venous catheter tips were collected aseptically for microbiological analysis.Results & Conclusion: CLRBSI was diagnosed in (32/150) patients and the rate of CVC- Blood stream infection number of CVC days was calculated as 17.5 per 1000 catheter days. The mean age of cases was observed to be 51 yrs. Patients from surgical ICU; signs of inflammation around catheter site, length of ICU stay, having underlying co-morbid conditions were significantly associated with CLRBSI. Gram positive organisms was the most common isolate.In our study duration of catheter more than seven days was associated with higher colonization rate. Hence regular surveillance for infection associated with them is essential.