¬¬Mapping the ABO Blood Group Landscape :Insights into Oral Cancer and Precancerous Lesions

Abstract

Introduction: Substantial literatures have revealed a connection between ABO blood group and cancer and our study seeks to explore the clinical significance of ABO blood groups in providing insight into the prevention and early detection of Oral Potentially Malignant Disorders (OPMDs) and Oral Cancer.
Materials & Methods: This study was conducted with 140 study participants. These cases were equally divided into 4 groups comprising of control, OSMF, Leukoplakia and Oral cancer respectively. Detailed history regarding tobacco and areca nut consumption was obtained and recorded. The ABO blood group determination was done using Rapid Slide Method. Results obtained were statistically analysed using Pearson’s chi-square test and significant results (P value <0.05) were further processed for logistic regression (odds ratio) analysis.
Results: Through meticulous analysis, we established a noteworthy correlation between blood group ‘B’ and heightened susceptibility (71.43%) to the development of oral cancer.
Conclusion: Individuals with blood group 'B' were at 6.25 times higher risk of developing oral cancer as compared with other blood groups thus emphasizing the importance of such readily accessible mass screening methods.