ORAL SQUAMOUS CELL CARCINOMA: EFFECT OF TOBACCO AND ALCOHOL ON CANCER LOCATION
DOI:
https://doi.org/10.70135/seejph.vi.4188Abstract
Introduction- The root causes of oral squamous cell malignancies (OSCC) have been identified, however little research has concentrated on etiological distinctions between affected oral cavity regions. Methodology: A cross-sectional analysis of patients with primary OSCC was undertaken retrospectively. The patients' self-reported history of tobacco smoking and alcohol use was explained by tumour site, age, gender, tumour size, and lymph node status in a logistic regression model. The data on smoking and alcohol consumption was gathered from a patient background form. Results-In 519 patients, tumors occurred most often in the tongue (51%), gingiva (21%), or floor of the mouth (FOM; 15%). FOM had 26-fold greater odds for a history of smoking and alcohol use than other tumor sites (OR=25.78; 95% CI: 8.02–82.95; p<0.001). Gingival and buccal sites were associated significantly less with smoking and alcohol use (OR=0.43, 95% CI: 0.28–0.67; p<0.001 and OR=0.47; 95% CI: 0.25–0.92; p<0.026, respectively). Conclusions-OSCC of oral cavity sites has notable differences in etiology. FOM seems to be related almost exclusively to conventional smoking and heavy alcohol use.
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