ANALYSIS OF THE INCIDENCE OF PREECLAMPSIA IN PREGNANT WOMEN WITH CONSUMPTION OF HERBAL MEDICINE CONTAINING CHOLIN, CITRININ, DIBUTYL PHTHALATE DURING PREGNANCY
DOI:
https://doi.org/10.70135/seejph.vi.3432Abstract
Preeclampsia is the second leading cause of maternal death globally each year associated with pregnancy, characterized by elevated blood pressure and proteinuria that usually appear during the second trimester or after 20 weeks. One of the natural medicines in Indonesia is "Jamu" which refers to a traditional drink of the Indonesian people used to prevent and treat diseases. Research on the content of compounds in jamu and their impact on the health of pregnant women, especially preeclampsia, is still limited. The results of LCMS analysis of the types of jamu commonly consumed in Boyolali Regency, namely papaya leaf decoction and sinom jamu, contain compounds such as dibutyl phthlate, citrinin, and cholin, which have the potential to affect sFlt1 levels. This study aims to analyze the differences in cholin, citrinin, and dibutyl phthalate (DBP) levels in the urine of pregnant women with preeclampsia (PE) and without PE, as well as the impact of herbal medicine consumption on the levels of these compounds. Using an analytic observational design and case-control study method, this study involved 110 pregnant women at Waras Wiris Andong Hospital in Boyolali Regency from January to July 2024. The results showed higher levels of choline and critinin in the PE group compared to non-PE, while DBP levels were higher in the non-PE group. Pregnant women who consumed herbal medicine had higher levels of choline and critinin. However, there was no significant correlation between the three compounds and the incidence of PE. These findings suggest significant differences in urinary compound levels based on PE status and herbal medicine consumption, although there is no simultaneous correlation with PE incidence.
Downloads
Published
How to Cite
Issue
Section
License

This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.