Association between Cardiac Enzymes Level in Type 2 Diabetes Mellitus from Jazan Region, Saudi Arabia

Authors

  • Mohammad Shane Alam ,Yahia A. Kaabi , Md. Mazharul Hoque,Farhana Riyaz Shah,Muhammad H. Khawaji , Mohammad Suhail Akhter,Zaki H Hakami, Yahia Mjery

DOI:

https://doi.org/10.70135/seejph.vi.3429

Abstract

Diabetes mellitus is characterized by deficiencies in insulin secretion and action, often leading to complications such as cardiac dysfunction associated with insulin-resistance syndrome. This study aimed to investigate the associations between serum cardiac enzyme levels (lactate dehydrogenase [LDH] and creatine kinase-MB [CK-MB]) and the incidence of type 2 diabetes mellitus in the Jazan population. Conducted at the MLT-Biochemistry laboratory of the College of Applied Medical Sciences, Jazan University, Saudi Arabia, the study involved the collection of 5 ml blood samples from 55 patients with type 2 diabetes and 35 control subjects. The mean (±S.D.) levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the control group were found to be 12.13±0.70 and 17.47±0.70 U/L, respectively, while in diabetic patients, the levels were significantly elevated at 20.55±1.90 and 24.15±2.10 U/L. Statistical analysis revealed significant differences in the means of ALT and AST levels between the two groups. The findings indicate that individuals with type 2 diabetes exhibit markedly higher serum liver enzyme levels compared to non-diabetic individuals, highlighting a greater incidence of liver function test (LFT) abnormalities in diabetic subjects. This study underscores the need for monitoring liver enzyme levels in patients with type 2 diabetes to better understand the associated risks and complications.

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Published

2025-01-11

How to Cite

Mohammad Shane Alam ,Yahia A. Kaabi , Md. Mazharul Hoque,Farhana Riyaz Shah,Muhammad H. Khawaji , Mohammad Suhail Akhter,Zaki H Hakami, Yahia Mjery. (2025). Association between Cardiac Enzymes Level in Type 2 Diabetes Mellitus from Jazan Region, Saudi Arabia. South Eastern European Journal of Public Health, 280–286. https://doi.org/10.70135/seejph.vi.3429

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