Innovative Pharmacological Approaches in Targeting Drug Resistance Mechanisms: A Biomedicine Perspective

Abstract

Introduction: Drug resistance is a major challenge in the treatment of infectious diseases and cancer. Complex drug resistance mechanisms, such as changes in molecular targets, increased drug effusion, and DNA repair mechanisms, hamper the effectiveness of conventional therapies.
Objectives: This study aims to identify innovative pharmacological approaches that can overcome drug resistance.
Methods: This study uses a qualitative method with a descriptive-analytical approach, which aims to explore in depth innovative pharmacological approaches in targeting drug resistance mechanisms. Qualitative methods were chosen because they allow for a more in-depth understanding of the phenomenon of drug resistance from a biomedical perspective, as well as providing space to identify and explain important findings that could lead to innovations in drug therapy.
Results: This study explored nanotechnology-based strategies, combination therapy, the use of specific inhibitors, as well as gene therapy-based approaches. The results show that these strategies have the potential to improve therapeutic effectiveness by targeting specific resistance mechanisms.
Conclusions: Innovative pharmacological approaches, such as nanotechnology, combination therapy and gene therapy, offer promising solutions to overcome drug resistance mechanisms. Further research is needed to test the effectiveness and safety of these strategies on a clinical scale.