Effects of Ropivacaine with and without Dexmedetomidine on Hemodynamic Responses During Laryngoscopy and Intubation: A Randomized Double-Blind Study

Abstract

Introduction: The study compares the effectiveness of airway nebulization with ropivacaine 0.5% alone and in combination, highlighting the potential benefits of these medications. Aims: The study evaluates ropivacaine 0.5% nebulization's effectiveness in reducing pressor response to intubation, assesses potential adverse effects, and compares the dose-sparing effect of propofol and sedation. Methodology: A randomized clinical study at Krishna Hospital compared airway nebulism with piroxicam and dexmedetomidine in 60 patients aged 18-60, focusing on treating hypotension and heart rate decline. Results: The study compared 60 participants in two treatment groups: RD and R alone, finding no significant difference in age, gender, weight, or ASA status. Discussion: The study compared the effectiveness of nebulized ropivacaine alone or combined with dexmedetomidine in reducing pressor response to laryngoscopy and intubation in 60 patients. Results showed that ropivacaine with dexmedetomidine significantly reduced heart rates and systolic blood pressure. Conclusion: The study shows that nebulized ropivacaine and dexmedetomidine significantly reduce pressor response during laryngoscopy and intubation, while also enhancing propofol's dose-sparing benefits and increasing sedative effects.