Study of Fasting Lipid Profile and National Early Warning Score in Patients of Sepsis

Abstract

Introduction
Sepsis is a life-threatening condition requiring early recognition and management to reduce mortality and morbidity. This study aimed to assess fasting lipid profiles and National Early Warning Scores (NEWS) in sepsis patients and their association with outcomes.
Methodology
A prospective analytical study was conducted at KIMS, Karad, involving 100 sepsis patients aged 18-75 years. Data collection included vital signs, clinical evaluations, and fasting lipid profile measurements. Statistical analysis was performed using SPSS software, with chi-square and t-tests to assess associations.
Results
The mean age of the patients was 58.04 ± 17.48 years, with a gender distribution of 61% male and 39% female. Survivors constituted 61% of the study population, while 39% were non-survivors. Significant lipid profile derangements were observed among non-survivors, including lower HDL levels (31.87 ± 13.17 mg/dL) and higher total cholesterol (189.48 ± 51.27 mg/dL), triglycerides (172.21 ± 67.38 mg/dL), LDL (89.21 ± 19.65 mg/dL), and VLDL (29.71 ± 9.30 mg/dL) compared to survivors. Non-survivors also had a mean NEWS score of 12.31 ± 2.81, significantly higher than the 9.87 ± 2.23 observed in survivors, indicating severe illness and increased mortality risk.
Conclusion
The study highlights the importance of monitoring lipid profiles and NEWS in sepsis patients, as significant associations were found between these parameters and patient outcomes. Elevated lipid levels and higher NEWS scores were associated with increased mortality, suggesting their potential utility in risk stratification and management of sepsis.
Categories: Emergency Medicine, Internal Medicine, Infectious Disease