Evaluation the Levels of Yap1 Protein and NF-Κb in Serum of Women with Breast Cancer

Abstract

Breast cancer (BC) is the type of cancer that is most frequently diagnosed and is the primary cause of cancer-related deaths in women globally. BC is intimately linked to both apoptosis and inflammation.   This study aimed to evaluate NF-kappaB (NF-κB) and Yes-associated protein (Yap1) biomarkers in the serum of women patients with (BC).

This case-control research recruited a total of 90 women, consisting of 60 women diagnosed with breast cancer and 30 healthy controls of the same age. This research detected a statistically significant rise (P<0.05) in the levels of NF-κB and Yap1 in the serum of the BC group compared to the control group. from the results of Receiver operating characteristic (ROC) analysis, the present results indicate an optimal NF-κB cut‑off value of more than 3.06 ng/ml resulted in an AUC value of 0.934. And is considered an excellent diagnostic marker, also. An optimal Yap1cutt-off value of more than 13.72 ng/ml resulted in an AUC value of 0.997 Yap1, while There was no significant difference P>0.05 in NF-κB and Yap1 levels among BC women according to clinical-pathological, molecular type and phenotype clinical and pathological characteristics.

We conclude that These results indicate the roles of NFκB and Yap1 as biomarkers for breast cancer diagnosis.