Estimation of some antioxidants and liver enzymes parameters in rats infected with Entamoeba histolytica and the extent of the therapeutic effect of gold nanoparticles

Abstract

This study was conducted on patients visiting Tikrit Teaching Hospital in Tikrit city and visiting some private laboratories in Al-Alam district for the period from the beginning of January 2023 to the end of December 2023. 548 stools were collected and the percentage of infection with the amoeba Entamoeba histolytica was 29.92% for 164 samples positive for microscopic examination. The study included the biochemical aspects that studied the effect of infection with the amoeba parasite on some antioxidants of infected rats treated with different concentrations of gold nanoparticles. It was noted that a significant increase occurred in infected rats treated with different concentrations of gold nanoparticles when compared with the control group at a probability level of 0.01 in Glutathione (GSH), Malondialdehyde (MDA). The aspects that studied the effect of infection with the amoeba parasite on some liver enzymes of infected rats treated with different concentrations of gold nanoparticles, it was noted that there was a significant increase in infected rats treated with different concentrations of gold nanoparticles when compared with the control group at a probability level of 0.05 in (AST) Aspartate amino transfrase, Alanine ameno transfrase (ALT).