Antibacterial Activity of sonicated Zingiber Officinale Rhizome Extract on Some Bacteria Isolated from Otitis media Patients

Abstract

Background: Zingiber officinale is an herbaceous plant that belongs to the Zingiber officinale family Zingiraceae   it is a abundant in the countries of east India, China and Sri Lanka as well as in some Arab countries.

Materials and Procedures: The purpose of this study was to evaluate the ethanolic sonicated of zingiber officinale Rhizome against the pathogenic bacteria (Streptococcus) isolated from patient of ear infection. 112 clinical specimens were collected from patient from Babylon hospital of both genders and different ages. From 1/October /2022 to 1/April /2023. The antibiotic susceptibility test was performed. The antimicrobial activity of sonicated ethanolic of zingiber officinale Rhizomes, the (MIC) the (MBC) of sonicated ethanolic of zingiber officinale of all isolates were determined.

Result: The results of isolation 100(899.3%) specimens gave positive growth from 42 females and 58 from males, The isolates of Streptococcus isolates showed sensitivity to [Chloramphenicol, Vancomycin, but show resistance to Gentamycin, Clindamycin, Tetracyclines, Azithromycin, Erythromycin], The antimicrobial activity of sonicated ethanolic They showed (27,40,15) mm for sonicated ethanolic, sonicated aqueous, and (27,40,15) mm for sonicated ethanolic. The antimicrobial agents of sonicated aqueous and ethanolic extract by three different methods first (FESEM) was showed these range of sonicated particles between (10.20-27.28) µm (XRD) that showed (23.601-44.015), third (FTIR) was used in range 400-4000cm- the results were showed 64 Mg/l MIC,128mg/l MBC for Streptococcus

Conclusion:  In this study, it was found that the highest infection rate at the (1-15) years category and the number of meals with otitis infections is more than females. It was showed that the otitis infection patients in the Urban regions with highest percentage with the lowest percentage observed in rural regions and rate of chronic otitis infections as more that the rate of acute otitis infections.