Studies On Bio-Evaluation Of Anticonvulsant And Neuroprotective Activity Of Epiphyllum Oxypetalum And Tradescantia Spathacea Using Animal Models

Abstract

In recent times, many folks with convulsions not having proper seizure control though there is significant advancement in medications. A common issue observed with these medications is the adverse cognitive effect with other side effect like anxiety. That’s why people still need anticonvulsant drugs without such side effects. For holistic approach, many of the natural resources can have antiepileptic action without such side effects which are scientifically not proven. In this study we established designed to check the neurobehavioral and neuro-protective results of Epiphyllum Oxypetalum and Tradescantia Spathacea evaluated in Pentylenetetrazol (PTZ) kindling model of epilepsy in rats. As carried out in our previous research to check anticonvulsant properties of EO and TS, to induce kindling a 35 mg/kg dose of PTZ was injected i.p. in every 48 hrs for 30 days. Spatial memory performance was tested using Morris water maze and black and light compartment model, following which brains were then decapitated for oxidative stress biomarker study, biochemical analysis (AchE and GABA T estimations) and histopathological investigations. EO and TS was able to minimize oxidative stress and enhance memory in Rats indicating these plants extracts have neuroprotective properties as well which is beneficial results to retain cognitive effects that usually happens in chronic epilepsy.