Investigate the extent impact of body mass index towards origins human primiparous colostrum IgA, IL5 and TNFα profile

Abstract

Background
Excess macronutrients provoke the inflammatory mediators release eading a pro-inflammatory microenvirontment and oxidative stress. Consequently, the differential of maternal environments may induce immunologic composition of breast milk may vary considerably. This paper explores the intricate relationship between body mass index (BMI) to human colostrum immunoglobulin A (IgA),tumor necrosis factor 1 alpha (TNF-α), and interleukin 5(IL-5) concentrration variability.
Methods
We collected colostrum samples from 150 primiparous women within 24 h post-partum. Weight and height measurement were conducted to calculate participant BMI. Enzymelinked immunosorbent assay was used to analyse the IgA, TNF-α, IL-5 concentrations.
Result
This work revealed that the highest IgA levels of colostrum milk were confirmed in lactating mother who had BMI >30kg/m2 (IgA 6.05±0.3ng/mL). The highest levels of colostrum TNF-α were confirmed in lactating mothers who had overweight BMI (239.04±0.8ng/mL).Those lactating mothers who had normal range BMI (18.5–22.9 kg/m2) showed the highestIL-5 levels in colostrum (113.81±0.4ng/mL). Moreover, maternal BMI had no significant influence on the IgA, TNF-α and IL-5 levels of colostrum, but Colostrum IgA levels were significantly different based on BMI category (p=0.005) .
Conclusion
The findings suggest that immunoglobulin A composition in breast milk vary depending on maternal BMI category.