EXPLORING THE CORRELATIONBETWEEN SERUM LEPTIN LEVELS AND OBESITY ASSOCIATED COGNITIVE DYSFUNCTIONIN THE BACKGROUND OF SYSTEMIC INFLAMMATION–AN OBSERVATIONAL STUDY

Abstract

Previous studies have stated the correlation of leptin resistant obesity with cognitive dysfunction in severe cognitive dysfunctional disorders like Alzheimer’s and Parkinson’s but the correlation of leptin to mild cognitive dysfunction in obese individuals with no disorders is yet to be explored. The correlation of level of systemic inflammation with the level of cognitive decline is also to be explored.In this study we aimed to correlate the serum leptin levels with cognitive dysfunction in obese individuals with varying BMI levels and to correlate the systemic inflammatory marker levels with leptin. We collected blood samples to analyse serum leptin and systemic inflammatory markers and correlated them with BMI and cognitive functions using neuro - cognitive scale. We found a positive correlation between the metabolic parameters like BMI and leptin with systemic inflammatory markers indicating the pathophysiology behind neurodegeneration triggered by inflammation. We also found a negative correlation of cognitive state with BMI and leptin in obese individuals with no known neurodegenerative disorders