Zinc Oxide-Based Endodontic Sealer with Proanthocyanidin-PLGA Nanoparticles: Synthesis and Physical Characterization

Abstract

This study developed a zinc oxide-based endodontic sealer incorporating proanthocyanidin nanoparticles (PAC-NPs) encapsulated in poly(lactic-co-glycolic acid) (PLGA), utilizing PAC’s proven ability to enhance dentine collagen stability. The formulation was designed to provide both antimicrobial and collagen-stabilizing benefits, aiming to improve dentine-sealer interface integrity and prolong the functional lifespan of root canal treatments. Chemical characterization was conducted using Fourier Transform Infrared (ATR-FTIR) spectroscopy, confirming the presence of Zn-O and C=O bonds, indicative of the successful integration of zinc oxide and encapsulated PAC. Physical properties, including flow, setting time, solubility, and dimensional stability, were evaluated according to ISO 6876:2012 and ANSI/ADA standards 57, with the sealer meeting all clinical performance criteria. This preliminary characterization of the physical and chemical properties establishes a basis for further in vitro studies on the mechanical and biological performance of the sealer, aimed at validating its potential to enhance dentine collagen stabilization and material durability in endodontic applications.